Menu UF Health Home Menu

Barry Setlow, Ph.D.

Contact Information:
Dr. Barry Setlow
Department of Psychiatry
University of Florida College of Medicine
PO Box 100256
Gainesville, FL 32610-0256
Office: L1-179, MBI Building
Phone: 294-5203 (office), 294-5047 (lab)

Associate Professor, Departments of Psychiatry and Neuroscience, University of Florida College of Medicine, Gainesville, FL

Research Area:
My research concerns interactions between drugs of abuse and decision-making.

1994 B.A. in Psychology, Yale University
1998 Ph.D. in Biological Sciences, Department of Psychobiology, University of California, Irvine.  Dr. James L. McGaugh, Chair
1998-2002 Postdoctoral Fellow, Department of Psychological and Brain Sciences, Johns Hopkins University, Laboratory of Dr. Michela Gallagher

Current Research:
Much of the research in Dr. Setlow’s laboratory concerns interactions between decision-making processes and drugs of abuse. In some of his research, they investigate the long-term effects of chronic exposure to drugs of abuse on cognitive outcomes, with a particular focus on different types of decision-making processes (for example, risky and impulsive decision-making) and the neural mechanisms underlying drug-induced alterations in such processes. In other research, they investigate how individual differences in risky and impulsive decision-making predict propensity for future drug use. In all of this research, they use a variety of techniques and animal models to identify behavioral and neurobiological mechanisms that mediate relationships between decision-making and drug abuse, with the ultimate goal of identifying therapeutic targets for both maladaptive decision-making and drug abuse.

Recent Publications:

Simon, N. W., Mendez, I. A., & Setlow, B.  (2007). Cocaine exposure causes long-term increases in impulsive choice behavior. Behavioral Neuroscience. 121, 543-549.

Mendez, I. A., Williams, M. T., Bhavsar, A., Lu, A. P., Bizon, J. L., & Setlow, B. (2009). Long-lasting sensitization of reward-directed behavior by amphetamine. Behavioural Brain Research. 201, 74-79.

Simon, N. W., Gilbert, R. J., Mayse, J. D., Bizon, J. L., & Setlow, B. (2009). Balancing risk and reward: A rat model of risky decision-making. Neuropsychopharmacology. 34, 2208-2217.

Setlow, B., Mendez, I. A., Mitchell, M. R., & Simon, N. W. (2009). Effects of chronic administration of drugs of abuse on impulsive choice (delay discounting) in animal models. Behavioural Pharmacology. 20, 380-389.

Mendez, I. A., Simon, N. W., Hart, N., Mitchell, M. R., Nation, J. R., Wellman, P. J., & Setlow, B. (2010). Self-administered cocaine causes lasting increases in impulsive choice in a delay discounting task. Behavioral Neuroscience. 124, 470-477.

Mitchell, M. R., Vokes, C. M., Blankenship, A. L., Simon, N. W., & Setlow, B. (2011). Effects of acute administration of nicotine, amphetamine, diazepam, morphine, and ethanol on risky decision-making in rats. Psychopharmacology. 218, 703-712.

Simon N. W., Montgomery, K. S., Beas, B. S., Mitchell, M. R., LaSarge, C. L., Mendez, I. A., Baneulos, C., Vokes, C. M., Taylor, A. B., Haberman, R. P., Bizon, J. L., & Setlow, B. (2011). Dopaminergic modulation of risky decision-making. The Journal of Neuroscience. 31, 17460-17470.

Banuelos, C., Gilbert, R. J., Montgomery, K. S., Fincher, A. S., Wang, H., Frye, G. D., Setlow, B., & Bizon, J. L. (2012). Altered spatial learning and delay discounting in a rat model of human third trimester binge ethanol exposure. Behavioural Pharmacology. 23, 54-65.

Mitchell, M. R., Mendez, I. A., Vokes, C. M., Damborsky, J. C., Winzer-Serhan, U. H., & Setlow, B. (2012). Effects of developmental nicotine exposure in rats on decision-making in adulthood. Behavioural Pharmacology. 23, 34-42.

Wallis, D., Hill, D. S., Mendez, I. A., Abbott, L. C., Finnell, R. H., Wellman, P. J., & Setlow, B. (2012). Initial characterization of mice null for Lphn3, a gene implicated in ADHD and addiction. Brain Research. 1463, 85-92.

Mendez, I.A., Gilbert, R.J., Bizon, J.L., & Setlow B. (in press). Effects of acute administration of nicotinic and muscarinic cholinergic agonists and antagonists on performance in different cost-benefit decision making tasks in rats. Psychopharmacology.