John S. Markowitz, Pharm.D.
Dr. John S. Markowitz
Department of Pharmacotherapy and Translational Research
University of Florida College of Pharmacy
1600 SW Archer Road, Rm. PG-23
Gainesville, FL 32610-0486
Phone: (352) 273-6262
Professor, Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL.
Dr. Markowitz’s research is focused on adverse drug reactions, drug-drug interactions, and the role of genetic variability in drug metabolizing enzymes and transporters in clinical response to therapeutic agents.
1984 B.S. in Biology/Microbiology, Memphis State University
1990 Pharm. D., University of Tennessee College of Pharmacy
1991 Resident, University of Tennessee College of Pharmacy
Board Certified Psychiatric Pharmacist (BCPP) # 496267, 1997, 2004 (by re-exam); Credentialed by the Board of Pharmaceutical Specialties (BPS)
Dr. Markowitz’s research focus is based upon his long standing interest in adverse drug reactions, drug-drug interactions, and the role of genetic variability in drug metabolizing enzymes and transporters in clinical response to therapeutic agents. Current and recent research has encompassed complementary in vitro and in vivo investigations incorporating cell culture and the development of novel cell lines, pharmacokinetic and pharmacodynamic studies in transgenic animals, as well as the conduct of normal volunteer studies directed at the assessment of drug-drug and botantical-drug interactions. He has received research support from both the pharmaceutical industry and the National Institutes of Health.
Zhu H-J, Appel DI, Jiang Y, Markowitz JS. Age and sex-related expression and activity of carboxylesterase 1 and 2 in mouse and human liver. Drug Metab Dispos 2009;37:1819-1825.
Zhu H-J, Appel DI, Peterson YK, Wang Z, Markowitz JS. Identification of selected therapeutic agents as inhibitors of carboxylesterase 1: Potential sources of metabolic drug interactions. Toxicology 2010;270:59-65.
Zhu HJ, Appel DI, Gründemann D, Markowitz JS. Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. J Neurochemistry 2010;114:142–9.
ZhuHJ, PatrickKS, Markowitz JS.Enantiospecific determination of dl-methylphenidate and dl-ethylphenidate in plasma by liquid chromatography-tandem mass spectrometry: Application to human ethanol interactions. J Chromatogr B; 2011;879:783-88.
Gillis NK, Zhu H-J, Markowitz JS. An in vitro evaluation of guanfacine as a substrate for P-glycoprotein. Neuropychiatric Disease and Treatment 2011;7:501-5.
Appel DI, Zhu H-J, Newcorn JH, Markowitz JS. A liquid chromatography/tandem mass spectrometry assay for the analysis of atomoxetine in human plasma and in vitro cellular samples. Biomedical Chromatography (in press, 2011).