Habibeh Khoshbouei, Pharm. D., Ph.D.

Contact Information

Dr. Habibeh Khoshbouei
Department of Neuroscience
University of Florida, College of Medicine
Box 100244
Gainesville, FL 32610
Phone: (352)273-8115 (Office)
Fax: (352)392-8347
Email: habibeh@ufl.edu

Position

Dr. Khoshbouei is an Associate Professor in the Department of Neuroscience, University of Florida College of Medicine, and has a joint appointment in the Department of Psychiatry, University of Florida College of Medicine. She is also an Adjunct Associate Professor in the Department of Physiology, Meharry Medical College, Nashville, TN, and in the Department of Pharmacology, Vanderbilt University, Nashville, TN.

Research Area

Dr. Khoshbouei’s current research is primarily concerned with the effect of drugs, specifically methamphetamine, on the dopamine transporter.

Training

1982-1989: Pharm, D., University of Tehran, Iran School of Pharmacy
1993-1995: Graduate Masters in Neurobiology, University of Texas, San Antonio, TX
1995-2001: Ph.D. in Pharmacology, University of Texas, San Antonio, TX, Advisor: David Morilak, Ph.D.
2001-2002: Postdoctoral Fellow, Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX
2002-2004: Postdoctoral Fellow, Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN

Current Research

Dr. Khoshbouei’s current research focus is on dopamine transporter activity (DAT). She is specifically considering how methamphetamine and amphetamine differentially affect DAT, how alpha-synuclein regulates DAT, and the mechanism of manganese-induced changes in DAT.

Recent Publications

Goodwin JS, Larson GA, Swant J, Sen N, Javitch JA, Zahniser NR, De Felice LJ, Khoshbouei H. (2009) Amphetamine and methamphetamine differentially affect dopamine transporters in vitro and in vivo. J Biol Chem; 284(5):2978-2989.

Swant J, Chirwa S, Stanwood G, Khoshbouei H. (2010) Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus. PLoS One; 5(6):e11382.

Swant J, Goodwin JS, Ali AA, Gamble-George J, Chirwa S, Khoshbouei H. (2011) α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter. J Biol Chem; 286(51):43933-43943.

Li Z, Chadalapaka G, Ramesh A, Khoshbouei H, Maguire M, Safe S, Rhoades RE, Clark R, Jules G, McCallister M, Aschner M, Hood DB. (2012) PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain-oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. Toxicol Sci; 125(1):233-247.

Fennell A., Gamble-George J., Goodwin J.S., Ansah T., Swant J., Khoshbouei H. The pattern of METH exposure determines its mnemonic consequences. Psychopharmacology. Submitted.