Jay P. McLaughlin, Ph.D.
University of Florida
Department of Pharmacodynamics
College of Pharmacy
1345 Center Drive
Building JHMHC, Room P1-20A
P.O. Box 100487
Gainesville, Florida 32610
TEL: (352)-273-7207; FAX: (352)-273-7705
Associate Professor, Department of Pharmacodynamics.
Determining the neurobiological mechanisms contributing to addictive behavior, and finding novel therapeutic interventions to treat substance abuse.
University of California-Santa Cruz, B.A., 06/1989 Biology
University of Rochester, M.S., 05/1996 Neuroscience (Mentor: Jean Bidlack)
University of Rochester, Ph.D., 05/1998 Neuroscience (Mentor: Jean Bidlack)
University of Rochester, Postdoctoral, 07/1999 Neuroscience (Mentors: Jean Bidlack and Steve Dewhurst)
University of Washington, Postdoctoral, 02/2002 Neuroscience (Mentor: Charles Chavkin)
Dr. McLaughlin is broadly interested in questions examining the neurobiological basis of behavior, focusing on the molecular, pharmacological and neurological mechanisms underlying behavior and psychological disorders. The overall goal is to identify the neurobiological systems underlying these behaviors, characterize them, and develop new therapeutic interventions.
The lab is currently engaged in three main projects: 1) the screening of novel compounds as analgesics and therapeutics for drug abuse; 2) exploring mechanisms by which stress modulates reward and contributes to disorders of mood, drug abuse, learning and memory, and 3) examining biological mechanisms by which HIV mediates neuropathology and alters behavior.
McLaughlin JP, Marton-Popovici M, Chavkin C: Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. J. Neurosci. 23: 5674-5683, 2003. PMID: 12843270.
Aldrich JV, Patkar KA, McLaughlin JP: Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist. Proc. Natl. Acad. Sci USA., 106:18396-18401, 2009. PMCID: PMC2775281.
Sperling RE, Gomes SM, Sypek EI, Carey AN, McLaughlin JP: Endogenous kappa opioid mediation of stress-induced potentiation of ethanol conditioned place preference and self administration. Psychopharmacology (Berl.), 210(2):199-209, 2010. PMID: 20401606.
Aldrich JA, Senadheera SN, Ross NC, Ganno ML, Eans SO, McLaughlin JP: The macrocyclic peptide natural product CJ-15,208 is orally active and prevents reinstatement of extinguished cocaine seeking behavior. J. Nat. Prod., 76(3):433-438, 2013. PMID:23327691
Paris JJ, Carey AN, Shay CF, Gomes SM, He J, McLaughlin JP: Effects of conditional central expression of HIV-1 Tat protein to potentiate cocaine-mediated psychostimulation and reward among male mice. Neuropsychopharmacology, 39(2):380-388, 2014. (doi: 10.1038/npp.2013.201.) PMID: 23945478.