Lori Knackstedt, Ph.D.
Lori Knackstedt, PhD
Department of Psychology
University of Florida
PO Box 112250
Gainesville, FL 32611-2250
Dr. Knackstedt is an Assistant Professor in the Department of Psychology at the University of Florida, Gainesville, FL.
Dr. Knackstedt is interested in the neurobiology of drug addiction with a focus on the glutamate neurotransmitter system.
B.S. Bucknell University, Lewisburg, PA
Ph.D. University of California, Santa Barbara, Santa Barbara, CA
Dr. Knackstedt is focusing on gaining a better understanding of the neurochemical and molecular changes that occur following the learned response of drug self-administration in order to develop effective behavioral and pharmacological therapies for addiction. . Therefore, the primary goal of her research is to determine biological factors contributing to the long-term behavioral adaptations produced by cocaine and alcohol self-administration in rodents. Secondary to this is goal is exploring methods of counteracting these pathological neuroadaptations to reverse the pathologies of learning and memory which drive relapse to drug-seeking. Her current research is working to assess the role of the neurotransmitter glutamate in the nucleus accumbens in relapse to alcohol and cocaine. To do so, she uses animal models of drug self-administration and relapse to identify alterations in glutamate levels using microdialysis procedures and protein expression using western blotting. She targets the identified pathologies with pharmacotherapies and genetic approaches, such as AAV-mediated over-expression.
Reissner, K.J., Gipson, C.D, Phuong, K.T., Knackstedt, L.A., Scofield, M.D., Kalivas, P.W. Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addiction Biology Epub ahead of print, PMID: 24612076
Hadad NA, Knackstedt LA. Addicted to palatable foods: Comparing the neurobiology of Bulimia Nervosa to that of drug addiction. Psychopharmacology (Berl). Epub ahead of print, PMID: 24500676
Knackstedt LA, Trantham-Davidson H, Schwendt M. (2014). The role of ventral and dorsal striatum mGluR5 in relapse to cocaine-seeking and extinction learning. Addiction Biology, 19(1): 87-101. PMID:23710649
Trantham-Davidson H, LaLumiere RT, Reissner KJ, Kalivas PW, Knackstedt LA. (2012). Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training. Journal of Neuroscience, 32(36):12406-10. PMID:22956831
Trantham-Davidson H, Lalumiere RT, Reissner KJ, Kalivas PW, Knackstedt LA. (2012). Ceftriaxone Normalizes Nucleus Accumbens Synaptic Transmission, Glutamate Transport, and Export following Cocaine Self-Administration and Extinction Training. J Neurosci, 32(36):12406-10. PMID:22956831
Wang X, Moussawi K, Knackstedt L, Shen H, Kalivas PW. (2012). Role of mGluR5 neurotransmission in reinstated cocaine-seeking. Addiction Biology, [Epub ahead of print]. PMID: 22340009