Bin Liu, Ph.D.
Bin Liu, Ph.D.
Department of Pharmacodynamics
University of Florida
Gainesville, FL 32610
Associate Professor, Department of Pharmacodynamics, University of Florida College of Pharmacy; Investigator, McKnight Brain Institute, University of Florida.
We are interested in defining the role of neuroinflammation, particularly that of microglia, in neurodegeneration induced by a variety of neurotoxicants.
B.M., West China University of Medical Sciences, Chengdu, China
M.S., University of Massachusetts, Boston, MA
Ph.D., Wayne State University, Detroit, MI
NRSA Postdoctoral Associate, Duke University, Durham, NC
Our research focuses on the understanding the role of neuroinflammation in toxicant-induced neurodegeneration. In collaboration with Dr. Stevens of University of South Florida, we are employing global proteomic approaches to identify key molecular pathways that define the role of microglia in alcohol-induced neurotoxicity. We are also continuing our research in gaining understanding of neuroinflammation in neurodegeneration induced by pesticides, heavy metals and infectious agents. Our ultimate goal is to identify early-stage molecular markers of neurodegeneration as potential diagnostic tools and pivotal factors of neuroinflammation and neurodegeneration as candidate therapeutic targets.
Bell-Tamin H, Barber DS, Zhang P and Liu B, Stevens SM (2012) Proteomic analysis of rat microglia establishes a high-confidence reference dataset of over 3,000 proteins. Proteomics 12:246-250.
Liu B, Barber DS and Stevens SM (2011) Stable isotope labeling with amino acids in cell culture (SILAC)-based proteomic analysis of ethanol-induced protein expression profiles in microglia. Meth. Mol. Med. 829:551-565.
Sharma H, Zhang P, Barber DS and Liu B (2010) Organochlorine pesticides dieldrin and lindane induce cooperative toxicity in dopaminergic neurons: role of oxidative stress. Neurotoxicology 31:215-222.
Zhang P, Lokuta KM, Turner DE and Liu B (2010) Synergistic dopaminergic neurotoxicity of manganese and lipopolysaccharide: differential involvement of microglia and astroglia. J. Neurochem. 112:434-443.
Zhang P, Wong TA, Lokuta KM, Turner DE, Vujisic K and Liu B (2009) Microglia enhance manganese chloride-induced dopaminergic neurodegeneration: role of reactive oxygen species. Exp. Neurol. 217:219-230.
Dutta G, Zhang P and Liu B (2008) The LPS Parkinson disease model: mechanistic studies and drug discovery. Fundament. Clin. Pharmacol. 22:453-464
Liu B (2006) Modulation of microglial pro-inflammatory and neurotoxic activity as a strategy for the treatment of Parkinson’s disease. AAPS J. 8:606-621