Bin Liu, Ph.D.
Dr. Bin Liu
Department of Pharmacodynamics
University of Florida
Gainesville, FL 32610
Phone: (352) 273-7747
Fax: (352) 273-7705
Website: Department of Pharmacodynamics Profile
Associate Professor, Department of Pharmacodynamics, University of Florida College of Pharmacy
Investigator, McKnight Brain Institute, University of Florida
Investigator, University of Florida Center for Addiction Research & Education
B.M., West China University of Medical Sciences, Chengdu, China
M.S., University of Massachusetts, Boston, MA
Ph.D., Wayne State University, Detroit, MI
NRSA Postdoctoral Associate, Duke University, Durham, NC
Our laboratory has been studying the role of environmental agents that include pesticides, heavy metals and infectious agents in the development of neurological disorders including Parkinson’s disease, a degenerative movement disorder resulted from a progressive destruction of the nigrostriatal dopamine-releasing neurons in the midbrain. We are particularly interested in delineating the intricate interactions between the immune cells in the brain (microglia and astrocytes) and the affected neurons in response to environmental agents. Aberrant activation of glial cells, induced through interactions with environmental agents or in response to neuronal injuries can lead to the excessive production and accumulation of reactive oxygen and nitrogen species, proinflammatory cytokines and lipid mediators that contribute to the progressive neurodegenerative process. We are utilizing molecular, biochemical, cellular and whole animal approaches to decipher the various aspects of the neuroinflammation-mediated neurodegeneration. Our ultimate goal is to identify highly specific molecular mediators of neurodegeneration as potential therapeutic targets and/or diagnostic biomarkers.
See all publications at Dr. Liu’s Google Scholar Profile.
- Bell-Tamin H, Barber DS, Zhang P and Liu B, Stevens SM (2012) Proteomic analysis of rat microglia establishes a high-confidence reference dataset of over 3,000 proteins. Proteomics 12:246-250.
- Liu B, Barber DS and Stevens SM (2011) Stable isotope labeling with amino acids in cell culture (SILAC)-based proteomic analysis of ethanol-induced protein expression profiles in microglia. Meth. Mol. Med. 829:551-565.
- Sharma H, Zhang P, Barber DS and Liu B (2010) Organochlorine pesticides dieldrin and lindane induce cooperative toxicity in dopaminergic neurons: role of oxidative stress. Neurotoxicology 31:215-222.
- Zhang P, Lokuta KM, Turner DE and Liu B (2010) Synergistic dopaminergic neurotoxicity of manganese and lipopolysaccharide: differential involvement of microglia and astroglia. J. Neurochem. 112:434-443.
- Zhang P, Wong TA, Lokuta KM, Turner DE, Vujisic K and Liu B (2009) Microglia enhance manganese chloride-induced dopaminergic neurodegeneration: role of reactive oxygen species. Exp. Neurol. 217:219-230.
- Dutta G, Zhang P and Liu B (2008) The LPS Parkinson disease model: mechanistic studies and drug discovery. Fundament. Clin. Pharmacol. 22:453-464
- Liu B (2006) Modulation of microglial pro-inflammatory and neurotoxic activity as a strategy for the treatment of Parkinson’s disease. AAPS J. 8:606-621