Barry Setlow, Ph.D.


Check out Dr. Setlow’s Podcast Episode Here

Contact Information

Dr. Barry Setlow
Department of Psychiatry
University of Florida College of Medicine
PO Box 100256
Gainesville, FL 32610-0256
Office: L2-183, MBI Building
Office Phone: (352) 294-5203
Laboratory Phone: (352) 294-5047
Website: Department of Psychiatry Profile


Member, Executive Committee, University of Florida Center for Addiction Research & Education
Professor, Departments of Psychiatry, Neuroscience, & Psychology University of Florida College of Medicine


B.A., Psychology, Yale University
Ph.D., Biological Sciences, Department of Psychobiology, University of California, Irvine (Dr. James L. McGaugh, Chair)
Postdoctoral Fellow, Department of Psychological and Brain Sciences, Johns Hopkins University (Laboratory of Dr. Michela Gallagher)

Research Interests

Much of the research in Dr. Setlow’s laboratory concerns interactions between cognition, motivation, and addiction. In some of their work, they investigate how acute and chronic exposure to drugs of abuse affects cognitive and motivational outcomes, with a particular focus on risky and impulsive decision-making processes. In other work, they investigate the neural mechanisms of such decision-making processes, and how individual differences in decision-making predict propensity for future drug use. Dr. Setlow’s laboratory uses behavioral, pharmacological, biochemical, and electrophysiological approaches in rodent models to identify mechanisms that mediate relationships between decision-making and drug use, with the goal of identifying therapeutic targets for both disordered decision-making and addiction. In addition, they collaborate with other laboratories on projects concerning the behavioral and neural basis of age-related cognitive impairments.


  • Orsini, C. A., & Setlow, B. (2017). Sex differences in animal models of decision making. Journal of Neuroscience Research. 95, 260-269.
  • Colon-Perez, L. M., Tran, K., Thompson, K., Pace, M., Blum, K., Goldberger, B. A., Gold, M. S., Bruijnzeel, A. W., Setlow, B., & Febo, M. (2016). The psychoactive designer drug and bath salt constituent MDPV causes widespread disruption of brain functional connectivity. Neuropsychopharmacology. 41, 2352-2365.
  • Bruijnzeel, A. W., Qi, X., Guzhva, L. V., Wall, S., Deng, J. V., Gold, M. S., Febo, M., & Setlow, B. (2016). Behavioral characterization of the effects of cannabis smoke and anandamide in rats. PLoS ONE. 11, 11(4): e0153327.
  • Orsini, C. A., Trotta, R., Bizon, J. L., & Setlow, B. (2015). Dissociable roles for the basolateral amygdala and orbitofrontal cortex in decision-making under risk of punishment. The Journal of Neuroscience. 35, 1368-1379.
  • Mitchell, M. R., Weiss, V. G., Ouimet, D. J., Fuchs, R. A., Morgan, D. & Setlow, B. (2014). Intake-dependent effects of cocaine self-administration on impulsive choice in a delay discounting task. Behavioral Neuroscience. 128, 419-429.
  • Mitchell, M. R., Weiss, V. G., Beas, B. S., Morgan, D., Bizon, J. L., & Setlow, B. (2014). Adolescent risk taking, cocaine self-administration, and striatal dopamine signaling. Neuropsychopharmacology. 39, 955-962.

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