Barry Setlow, Ph.D.

Contact Information

Dr. Barry Setlow
Department of Psychiatry
University of Florida College of Medicine
PO Box 100256
Gainesville, FL 32610-0256
Office: L2-183, MBI Building
Phone: 294-5203 (office), 294-5047 (lab)


Professor, Departments of Psychiatry, Neuroscience, & Psychology University of Florida College of Medicine, Gainesville, FL

Research Area

My research concerns interactions between drugs of abuse and decision-making.


1994 B.A. in Psychology, Yale University
1998 Ph.D. in Biological Sciences, Department of Psychobiology, University of California, Irvine.  Dr. James L. McGaugh, Chair
1998-2002 Postdoctoral Fellow, Department of Psychological and Brain Sciences, Johns Hopkins University, Laboratory of Dr. Michela Gallagher

Current Research

Much of the research in my laboratory concerns interactions between decision-making processes and drugs of abuse. In some of this research, we investigate the long-term effects of chronic exposure to drugs of abuse on cognitive outcomes, with a particular focus on different types of decision-making processes (for example, risky and impulsive decision-making) and the neural mechanisms underlying drug-induced alterations in such processes. In other research, we investigate how individual differences in risky and impulsive decision-making predict propensity for future drug use. In all of this research, we use a variety of techniques (e.g., behavioral/cognitive testing, behavioral pharmacology, biochemistry, optogenetics, in vivo electrophysiology) to identify mechanisms that mediate relationships between decision-making and drug abuse, with the ultimate goal of identifying therapeutic targets for both maladaptive decision-making and addiction.

Recent Publications

Orsini, C. A., & Setlow, B. (2017). Sex differences in animal models of decision making. Journal of Neuroscience Research. 95, 260-269.

Colon-Perez, L. M., Tran, K., Thompson, K., Pace, M., Blum, K., Goldberger, B. A., Gold, M. S., Bruijnzeel, A. W., Setlow, B., & Febo, M. (2016). The psychoactive designer drug and bath salt constituent MDPV causes widespread disruption of brain functional connectivity. Neuropsychopharmacology. 41, 2352-2365.

Bruijnzeel, A. W., Qi, X., Guzhva, L. V., Wall, S., Deng, J. V., Gold, M. S., Febo, M., & Setlow, B. (2016). Behavioral characterization of the effects of cannabis smoke and anandamide in rats. PLoS ONE. 11, 11(4): e0153327.

Orsini, C. A., Trotta, R., Bizon, J. L., & Setlow, B. (2015). Dissociable roles for the basolateral amygdala and orbitofrontal cortex in decision-making under risk of punishment. The Journal of Neuroscience. 35, 1368-1379.

Mitchell, M. R., Weiss, V. G., Ouimet, D. J., Fuchs, R. A., Morgan, D. & Setlow, B. (2014). Intake-dependent effects of cocaine self-administration on impulsive choice in a delay discounting task. Behavioral Neuroscience. 128, 419-429.

Mitchell, M. R., Weiss, V. G., Beas, B. S., Morgan, D., Bizon, J. L., & Setlow, B. (2014). Adolescent risk taking, cocaine self-administration, and striatal dopamine signaling. Neuropsychopharmacology. 39, 955-962.