John S. Markowitz, Pharm.D.
Dr. John S. Markowitz
Department of Pharmacotherapy and Translational Research
University of Florida College of Pharmacy
1600 SW Archer Road, Rm. PG-23
Gainesville, FL 32610-0486
Phone: (352) 273-6262
Website: Department of Pharmacotherapy and Translational Research Profile
Professor, Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy
B.S. in Biology/Microbiology, Memphis State University
Pharm. D., University of Tennessee College of Pharmacy
Resident, University of Tennessee College of Pharmacy
Board Certified Psychiatric Pharmacist (BCPP) # 496267, 1997, 2004 (by re-exam); Credentialed by the Board of Pharmaceutical Specialties (BPS)
Dr. Markowitz’s research program has encompassed both in vitro and in vivo investigations including normal volunteer pharmacokinetic studies directed at the assessment of drug-drug interactions in psychopharmacology, botanical-drug interactions, as well as their associated clinical effects. More recently, the research program has focused on variability in drug metabolism, disposition, and therapeutic response as a consequence of genetic variability which influences both drug transporters and hepatic enzymes. He has received research support from both the pharmaceutical industry and the National Institutes of Health.
- Zhu H-J, Langaee TY, Gong Y, Wang X, Pepine CJ, Cooper-DeHoff RM, Johnson JA, Markowitz JS. CES1P1 variant −816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril. Eur J Clin Pharmacol 2016;72:681-687.
- Wang X, Zhu H-J, Munoz J, Gurley BJ, Markowitz JS. An ex vivo approach to botanical-drug interactions: A proof of concept study. J Ethnopharmacol 2015;163:149-156. (PMID: 25623616)
- Kawaguchi-Suzuki M, Frye RF, Zhu H-J, Brinda BJ, Chavin KD, Bernstein HJ, Markowitz JS. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Drug Metab Dispos 2014;42:1611-1616 (PMID: 25028567)
- Zhu HJ, Wang X, Gawronski B, Brinda B, Angiolillo D, Markowitz JS. Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation. J Pharmacol Exp Ther 2013;344:665-672. (PMID: 23275066)
- Zhu H-J, Brinda B, Froehlich TE, Markowitz JS. A discriminative genotypic method for detecting CES1A1 and CES1A2/CES1A3 genetic variants. Pharmacogenetics & Genomics 2012; 22:215-8. (PMID: 22237548)
- Zhu HJ, Appel DI, Gründemann D, Markowitz JS. Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. J Neurochemistry 2010;114:142–9. (PMID: 20402963)
- Zhu H-J, Patrick KS, Yuan H-J, Wang J-S, Donovan JL, DeVane, CL, Malcolm R, Johnson JA, Youngblood GL, Sweet DH, Langaee TY, Markowitz JS. Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: Clinical significance and molecular basis. Am J Hum Genetics 2008;82:1241-48. (PMID: 18485328)