Jay P. McLaughlin, Ph.D.


Contact Information

University of Florida
Department of Pharmacodynamics
College of Pharmacy
1345 Center Drive
P.O. Box 100487
Gainesville, Florida 32610
Office: Medical Science Building, P1-33
Phone: (352)-273-7207;
FAX: (352)-273-7705
Email: jmclaughlin@cop.ufl.edu
Website: Department of Pharmacodynamics Profile


Associate Professor, Department of Pharmacodynamics, University of Florida College of Pharmacy


B.A., Biology, University of California-Santa Cruz
M.S., Neuroscience, University of Rochester (Mentor: Jean Bidlack)
Ph.D., Neuroscience, University of Rochester (Mentor: Jean Bidlack)
Postdoctoral, Neuroscience, University of Rochester (Mentors: Jean Bidlack and Steve Dewhurst)
Postdoctoral, Neuroscience, University of Washington (Mentor: Charles Chavkin)

Research Interests

Dr. McLaughlin’s research goal is to identify the neurobiological systems underlying behavior, characterizing them and related psychological disorders to developing new therapeutic interventions utilizing molecular, pharmacological, anatomical and behavioral methods. His projects encompass both basic science and drug discovery elements.


  • Váradi A, Marrone GF, Eans SO, Ganno ML, Subrath JJ, Le Rouzic V, Hunkele A, Pasternak GW, McLaughlin JP, Majumdar S: Synthesis and characterization of a dual kappa-delta opioid receptor agonist analgesic blocking cocaine reward behavior. ACS Chem Neurosci, 6(11):1813-1824, 2015. PMID:26325040; PMCID: PMC4651729.
  • Mediouni S, Marcondes MCG, Miller C, McLaughlin JP, Valente ST: The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders. Frontiers in Microbiology, 6:1164, 2015. doi: 10.3389/fmicb.2015.01164. PMID:26557111; PMCID:PMC4615951.
  • Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L: Direct high throughput in vivo phenotypic screening: Identification of individual, novel antinociceptive compounds from a library of 734,821 pyrrolidine bis-piperazines. ACS Comb. Sci.,18(1):51-64, 2016. doi: 10.1021/acscombsci.5b00126. PMID: 26651386; PMCID: PMC4710894.
  • Smeets CJ, Zmorzynska J, Melo MN, Stargardt A, Dooley C, Bakalkin G, McLaughlin JP, Sinke RJ, Marrink SJ, Reits E, Verbeek DS: Altered secondary structure of Dynorphin A associates with loss of opioid signaling and NMDA-mediated excitotoxicity in SCA23. Human Molecular Genetics. 25(13):2728-2737, 2016. PMID: 27260403
  • Váradi A, Marrone GF, Palmer TC, Narayan A, Szabó MR, Le Rouzic V, Grinnell SG, Subrath JJ, Warner E, Kalra S, Hunkele A, Pagirsky J, Eans SO, Medina JM, Xu J, Pan Y-X, Pasternak GW, Borics A, McLaughlin JP, Majumdar S: Mitragynine/coryantheidine psuedoindoxyls as opioid analgesics with mu agonism and delta antagonism which do not recruit β-arrestin-2. J. Med Chem., 59(18): 8381-8397, 2016. PMID: 27556704
  • Spetea M, Eans SO, Ganno ML, Lantero A, Mairegger M, Toll L, Schmidhammer H, McLaughlin JP: Selective κ opioid receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice. Br J. Pharmacol., 174(15): 2444-2456, 2017. PMID: 28494108; PMCID: PMC5513865. DOI: 10.1111/bph.13854
  • Shao J, Houghten RA, Dooley C, Cazares M, McLaughlin JP, Eans SO, Ganno ML, Hoot MR, Giullianotti MA, Yu Y: A one-pot multicomponent approach to a new series of morphine derivatives and biological evaluation. Organic and Biomolecular Chemistry, 15(37): 7796-7801, 2017. PMID: 28875208. DOI: 10.1039/c7ob01924f.
  • McLaughlin JP, Paris JJ, Mintzopoulos D, Hymel KA, Kim JE, Cirino TJ, Gillis TE, Eans SO, Vitaliano G, Medina JM, Krapf RC, Stacy HM, Kaufman MJ: Conditional HIV-Tat protein expression induces depression-like effects and oxidative stress. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (BPCNNI), 2(7): 599-609, 2017. DOI: 10.1016/j.bpsc.2017.04.002.