Jeremy C. McIntyre, Ph.D.
Dr. Jeremy C. McIntyre
Department of Neuroscience
University of Florida
1149 Newell Drive
PO Box 100244
Gainesville, FL 32611-0244
Office Phone: (352) 294-8266
Lab Phone: (352) 273-9018
Websites: Department of Neuroscience Profile
Assistant Professor, Department of Neuroscience, University of Florida College of Medicine
Ph.D. (Physiology), University of Kentucky, Lexington, KY
Postdoctoral Fellow (Pharmacology), University of Michigan, Ann Arbor, MI
Postdoctoral Associate (Pharmacology), University of Florida, Gainesville, FL
The McIntyre Lab is broadly interested in the molecular mechanisms that underlie olfactory function. We study both the sensory neurons in the nasal cavity that detect odors in the environment as well as the neurons in the olfactory bulb that begin the neural processing of this information. The lab currently has several ongoing projects.
First, we are applying gene therapy approaches to correct congenital defects in the sense of smell. Currently we are focused on mutations affecting ion channel function. We are developing methods to delivery and re-express functional copies of these channels to the olfactory epithelium to restore olfactory function. To evaluate the effectiveness of these therapies we used immunofluorescence, calcium imaging, electrophysiology and behavioral experiments.
In the olfactory bulb, we are studying how physiological conditions affects odor processing. Input into the olfactory bulb from higher regions of the brain are known to modulate how neurons in the bulb respond to odors, making them more or less responsive. We are investigating neuromodulators involved in hunger/satiety signaling and those that change with aging. Our work focuses on several GPCRs involved in these signaling pathways that localize to the primary cilia that project from neuronal cell bodies. Cilia are critical for cellular function, and disruptions of cilia function can lead to numerous disease phenotypes. The lab is working to further understand the role of cilia in integrating a variety of signals and the modulation of neuronal processes. To achieve these goals, we have developed several new mouse models to look at cell specific ablation of cilia and immunofluorescence and confocal microscopy, calcium imaging, electrophysiology, molecular biology and behavior.
- Green WW, Uytingco CR, Ukhanov K, Kolb Z, Moretta J, McIntyre JC, Martens JR. (2018) Peripheral gene therapeutic rescue of an olfactory ciliopathy restores sensory input, axonal pathfinding, and odor-guided behavior. J Neurosci. 0084-18. doi: 10.1523/JNEUROSCI.0084-18.2018
- Williams CL, Uytingco CR, Green WW, McIntyre JC, Ukanov K, Zimmerman AD, Shively DT, Zhang L, Nishimura DY, Sheffield VC, Martens JR. (2017) Gene Therapeutic Reversal of Peripheral Olfactory Impairment in Bardet-Biedl Syndrome. Molecular Therapy. Epub Feb 9th 2017. link
- Chen KS*, McIntyre JC*, Lieberman AP, Martens JR, Patil PG. (2016) Human spinal autografts of olfactory epithelial stem cells recapitulate donor site histology, maintaining proliferative and differentiation capacity many years after transplantation. Acta Neuropathologica Feb 2 2016. link
- Joiner AM*, Green WW*, McIntyre JC, Allen B, Schwob JE, Martens JR. (2015) Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium. J Neurosci 35(40):13761-72
- McIntyre JC, Joiner AM, Zhang L, Iniguez-Lluhi J, Martens JR. (2015) SUMOylation regulates the ciliary localization of olfactory signaling proteins. Journal of Cell Science. jcs.164673 PMID: 25908845 PMCID: PMC4457158 link
- Ryland KE, Svoboda LE, Vesely ED, McIntyre JC, Zhang L, Martens JR, Lawlor ER (2015) Polycomb-dependent repression of KCNA5 (Kv1.5 channel) promotes cancer cell survival. Oncogene. 34(35):4591-600. Epub 2014 Dec1. doi 10.1038/onc.2014.384 PMID: 25435365 PMCID: PMC4451446
- Williams CL, McIntyre JC, Norris S, Zhang L, Pei Q, Verhey K, Martens JR. (2014) Direct evidence for BBSome-associated IFT reveals unique transport properties of native mammalian cilia. Nature Communications 5, Article number: 5813 DOI: 10.1038/ncomms6813 PMID: 25504142 PMCID: PMC4284812 link
- Schumacher-Bass SM, Vesely ED, Zhang L, Ryland KE, McEwen DP, Chan PJ, Frasier CR, McIntyre JC, Shaw RM MD, Martens JR. (2014) A Role for Myosin V Motor Proteins in the Selective Delivery of Kv Channel Isoforms to the Membrane Surface of Cardiac Myocytes. Circ Research. 114(6):982-92. PMID:24508725 PMC4213814
- McIntyre JC, Davis EE, Joiner A, Williams CL, Tsai I, Jenkins PM, McEwen DP, Zhang L, Escobado J, Thomas S, Szymanska K, Johnson CA, Beales PL, Green ED, Mullikin JC, NISC Comparative Sequencing Program, Sabo A, Muzny DM, Gibbs RA, Attie-Bitach T, Yoder BK, Reed, RR, Katsanis N, Martens JR. (2012) Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model. Nature Medicine: 18(9):1423-8. PMID: 22941275 PMCID: PMC3645984