Dr. Marek Schwendt
Department of Psychology
University of Florida
P.O. Box 112250
Gainesville, FL 32611-2250
Dr. Schwendt is an Assistant Professor in the Department of Psychology at the University of Florida, Gainesville, FL.
Dr. Schwendt’s research focuses on psychostimulant induced neuroplasticity underlying persistent drug-seeking and cognitive impairments.
M.S., Comenius University, Bratislava, Slovakia
Ph.D., Institute of Exp. Endocrinology & University of P.J. Safarik, Bratislava, Slovakia
Postdoctoral Fellowship, Medical University of South Carolina, Charleston, SC
Dr. Schwendt is interested in what causes drug addiction to be a chronic relapsing disorder. He is interested in identifying cellular and molecular mechanisms underlying relapse and drug-induced cognitive deficits which persist well into abstinence. His research utilizes an animal model with high-face validity for human addiction: operant drug self-administration in combination with tasks designed to test memory performance in animals. In particular, his research attempts to elucidate the role of modulatory proteins that ‘fine-tune’ synaptic transmission during development of drug-induced neural plasticity, and further, to investigate whether in vivo manipulation of these proteins can attenuate or reverse drug-seeking and drug-induced cognitive deficits. Dr. Schwendt believes that characterization of the molecular underpinnings of the long-lasting behavioral consequences of repeated drug administration will provide critical insight into the psychopathology of drug addiction and related psychiatric disorders (including schizophrenia and depression).
Knackstedt L.A., Trantham-Davidson H.L., Schwendt M. The role of ventral and dorsal striatum mGluR5 in relapse to cocaine-seeking and extinction learning. Addiction Biology 19: 87-101, 2014.
Schwendt M., Reichel C.M., See R.E.: Extinction-dependent alterations in corticostriatal mGluR2/3 and mGluR7 receptors following chronic methamphetamine self-administration in rats. PLoS One, 7: e34299, 2012.
Schwendt M., McGinty J.F.: RGS4 overexpression in the rat dorsal striatum modulates mGluR5- and amphetamine-mediated behavior and signaling. Psychopharmacology, 221: 621-35, 2012.
Reichel C.M., Ramsey L.A., Schwendt M., McGinty J.F., See R.E.: Methamphetamine-induced changes in the object recognition memory circuit. Neuropharmacology, 62: 1119-26, 2012.
Reichel C.M., Schwendt M., McGinty J.F., Olive M.F., See R.E. Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5. Neuropsychopharm 36:782-92, 2011.