Lori Knackstedt, Ph.D.

Lori-Knackstedt

Check out Dr. Knackstedt’s Podcast Episode Here

Contact Information

Dr. Lori Knackstedt
Department of Psychology
University of Florida
PO Box 112250
Gainesville, FL 32611-2250
Office: 322 PSY
Phone: (352) 273-2185
Email: knack@ufl.edu
Website: Department of Psychology Profile
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Position

Associate Professor, Department of Psychology, University of Florida

Research Area

Dr. Knackstedt is interested in the neurobiology of drug addiction with a focus on the glutamate neurotransmitter system.

Training

B.S. in Biology, Magna cum laude, Bucknell University, Lewisburg, PA
Ph.D. University of California, Santa Barbara, Santa Barbara, CA (Advisor: Aaron Ettenberg)

Current Research

Dr. Knackstedt is focusing on gaining a better understanding of the neurochemical and molecular changes that occur following the learned response of drug self-administration in order to develop effective behavioral and pharmacological therapies for addiction.  Therefore, the primary goal of her research is to determine biological factors contributing to the long-term behavioral adaptations produced by cocaine and alcohol self-administration in rodents. Secondary to this is goal is exploring methods of counteracting these pathological neuroadaptations to reverse the pathologies of learning and memory which drive relapse to drug-seeking. Her current research is working to assess the role of the neurotransmitter glutamate in the nucleus accumbens in relapse to alcohol and cocaine. To do so, she uses animal models of drug self-administration and relapse to identify alterations in glutamate levels using microdialysis procedures and protein expression using western blotting. She targets the identified pathologies with pharmacotherapies and genetic approaches, such as AAV-mediated over-expression.

Recent Publications:

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